Actually got your catalog inquiry about the semaglutide intermediate and wanted to follow up directly — we've been supplying this specific building block for a while now, and most buyers go with the 99.9% purity because it cuts down on purification steps later. white to pale yellow powder form is pretty much standdard, and we've found it handles better than some competitors' material that tends to clump under humidity.
We're talking about Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH here, CAS 1662688-20-1, and the 1196.5 molecular weight is what you'd expect for this intermediate — it's tighter tolerance than most bulk suppliers manage, which matters when you're scaling up a semaglutide synthesis and don't want variability between batches. The HPLC purity is usually above 99.9% on our COAs, but we always include the full chromatogram so you can see the impurity profile yourself. 3 weeks or so is typical for UK delivrey form our warehose, give or take a few days depending on customs.
![Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH Structure](https://img.manufactry.com/2145741_0.png)
One thing that catches people off guard is that this intermediate isn't really suited for direct formulation work — it's a protected building block, not the final API, so you'll need to deprotect and couple it properly. We've had a few researchers ask about using it as-is, and it just won't work that way. The storage is straightforward though: keep it cool and dry, and it stays stable for 18 months or so without significant degradation.
What it does is give you cleaner coupling yields than the older Fmoc-Lysine derivatives because the AEEA spacers improve solubility in standard peptide synthesis solvents. We usually stock about 500 grams to 5 kilograms in the UK facility, but larger quantities need about 2-4 weeks lead time (check with us before ordering if you're in a rush). The pharmaceutical grade designation means every batch has full traceability paperwork, which some of our competitors skimp on.
Most buyers in the UK go with the 10-gram or 50-gram quantities first to validate their synthesis, then scale up — our company can customize packging to your preferred container size, whether that's amber vials or foil bags. Also, the price per gram drops significantly at 100 grams or more, so if you're planning multiple runs, it's worth ordering bulk upfront.