Tirzepatide, also known as LY3298176, is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. It is primarily developed for type 2 diabetes treatment research, showing superior efficacy in glucose control and weight reduction compared to other agents like Dulaglutide. Tirzepatide exhibits a higher affinity for GIP receptors, enhancing its ability to reduce hyperglycemia and support metabolic functions.
This peptide aids in slowing gastric emptying, preventing excessive liver sugar production, and stimulating insulin release from the pancreas when blood sugar levels are elevated. It contributes to better blood glucose management, reduces post-meal hyperglycemia, and lowers fasting insulin and glucose levels. Additionally, Tirzepatide can decrease appetite and caloric intake, inhibit weight gain, and has been shown to lower triglycerides and oxidative stress associated with high LDL. It promotes weight loss in obese subjects, improves leptin sensitivity, and facilitates the conversion of white fat to brown fat.
For research purposes only, Tirzepatide is supplied as a white powder with a purity exceeding 98%, as verified by Certificate of Analysis and HPLC reports. It should be stored in a dry, dark environment at 0-4°C for short-term use or -20°C for long-term preservation, with a shelf life of over two years when handled correctly. Solubility and drug formulation details are subject to further determination based on specific study requirements.