Semaglutide Side Effects: High Purity 99% White Powder for Research Use

Semaglutide is a novel GLP-1 receptor agonist (GLP-1RA) that has gained significant attention in pharmaceutical research. This peptide shares structural similarities with liraglutide but contains two key modifications that enhance its stability and bioavailability. The first modification involves replacing Gly with 2-aminoisobutyric acid (Aib) at position 2, while the second incorporates an octadecanoic diacid attached to Lys-26 through a PEG spacer and γ-glutamic acid linker.

These structural changes make Semaglutide more resistant to DPP-4 degradation compared to similar peptides, while the fatty acid moiety enables strong albumin binding, resulting in an extended half-life of approximately 7 days in humans. When studying semaglutide side effects, researchers note its glucose-dependent insulin secretion mechanism, glucagon suppression, delayed gastric emptying, and central appetite suppression effects.

In clinical research applications, Semaglutide demonstrates three primary benefits: significant hypoglycemic effects superior to standard therapies, substantial weight loss averaging 17-18% over 68 weeks in obese subjects, and cardiovascular benefits including reduced risk of major adverse events by 26% and non-fatal stroke by 39%. These effects make it valuable for studying metabolic syndrome, type 2 diabetes, and obesity-related conditions.

Potential semaglutide side effects under investigation include gastrointestinal symptoms, which are common among GLP-1 receptor agonists. Researchers emphasize the importance of monitoring these effects in clinical studies, particularly when evaluating long-term use. The peptide's safety profile and tolerability continue to be important areas of pharmaceutical research.

Our high purity Semaglutide (99% white powder) is provided exclusively for research purposes. Each batch undergoes rigorous quality control to ensure consistency and reliability for laboratory studies. The product is carefully packaged to maintain stability and shipped with proper documentation for research use only.