Retatrutide Acetate 99% Purity - UK Source for Semaglutide Research Materials

Retatrutide acetate, also known as LY3437943, is a triple agonist peptide targeting the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). It demonstrates high efficacy with EC50 values of 5.79 nM for human GCGR, 0.0643 nM for human GIPR, and 0.775 nM for human GLP-1R. In murine models, it shows EC50 values of 2.32 nM for GCGR, 0.191 nM for GIPR, and 0.794 nM for GLP-1R.

In vivo studies indicate that Retatrutide acetate engages with GCGR to improve glucose tolerance through GIP or GLP-1 receptor pathways. Activation via the glucagon receptor results in notable weight reduction and increased energy expenditure, making it a valuable compound for obesity-related research. This product is supplied as a lyophilized powder with a purity of 99%, ensuring reliability for experimental use.

This product is intended for research use only and is not for human consumption. Proper storage conditions include refrigeration, keeping the product dry and protected from light to maintain stability over its shelf life. Researchers in the UK looking for where to buy semaglutide uk can consider this high-quality alternative for their studies.