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Retatrutide (LY3437943) acetate is a triple agonist peptide targeting the glucagon receptor (GCGR), glucose - dependent insulinotropic polypeptide receptor (GIPR), and glucagon - like peptide - 1 receptor (GLP - 1R). It inhibits human GCGR, GIPR, and GLP - 1R with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively, and exhibits activity on mouse receptors with EC50 values of 2.32, 0.191, and 0.794 nM. In vivo, Retatrutide acetate enhances glucose tolerance and promotes weight reduction by increasing energy expenditure, making it valuable for obesity - related research.
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