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Over years of sourcing this compound form different suppliers, we’ve found that viability really hinges on purity — their published >99% is better than reagent grade for this appliction, though we always verify with our own HPLC since storage conditions can drift specs over time, and honestly the real-world consistency is what makes it worth keeping in our rotation.
It basically functions as a coenzyme for sirtuins and PARPs, so the molecular weight of 663.43 g/mol matters because you’re looking at roughly 1.5 micromoles per mg if you’re diluting for injection or cell work, and the reconstituted solution is stable about 20 days or so at 2-8°C, but don’t freeze it after it’s mixed or you’ll get precipitation issues we’ve seen cause data problems in murine models.
The lyophilized cake appearance is a practical check — if it’s off-white with no discoloration you’re usually good, and the 0.22 micron filtration step we do pre-use catches any aggregates that might have formed during shipping (check lead time if you’re ordering during summer as heat exposure can degrade some batches).
Now we typically stock the 250mg vials for smaller protocols and teh 500mg for larger dosing regimens, but one thing buyers don’t always realize is that this isn’t suited for oral studies as the bioavailability through that route is negligible after reconstitution—you’d want a different analog for that, and the CAS number 53-84-9 is the free acid, not a salt form.
Also we’ve found MOQ from this source is 10 vials minimum regardless of size, which is pretty standard for a pharmaceutical intermediate with COA traceability, but what it does is guarantee you’re getting a batch that hasn’t sat on a warehouse shelf for months given we rotate stock regularly.
Anyway those are the practical points we’ve gathered from about 18 months of regular orders, and the purity consistency has made them reliable option for our mitochondrial health knockout study series.
