Blue Sky Peptide PNC-27 is a membrane-active peptide designed for research applications. It binds to the HDM-2 protein expressed in cancer cell membranes of solid tissue tumor cells, inducing transmembrane pore formation specifically in cancer cells without affecting normal cells. This action leads to tumor cell necrosis independent of p53 activity.
The peptide includes p53 protein amino acid residues 12-26 from its HDM-2 binding domain, attached to a transmembrane-penetrating sequence known as the membrane residency peptide (MRP). Both PNC-27 and its variant PNC-28 demonstrate lethality to various cancer cells with IC50 values ranging from approximately 75 ug/ml to 200 ug/ml, while showing no adverse effects on normal or untransformed cells, even at high doses up to 500 ug/ml. This selectivity suggests minimal toxicity to bone marrow function, distinguishing it from many chemotherapeutic agents.
Blue Sky Peptide ensures high quality with products accompanied by a Certificate of Analysis (COA) and HPLC testing report. The manufacturing process adheres to ISO9001 standards, guaranteeing reliability and consistency for research purposes. This product is supplied as a white lyophilized powder with a purity greater than 99.0%. After reconstitution, it should be stored at 2°C to 8°C to maintain stability.




This product is intended for research use only and not for personal consumption. Always follow proper laboratory safety protocols when handling.
Great experience overall. The shipping was surprisingly fast, arriving well ahead of the estimated delivery window, which was a huge plus for my project timeline. The packaging was professional and secure, with all necessary documentation clearly included. Regarding quality, the product itself appears to be of high standard, exactly as described for research purposes. The communication from the supplier was prompt and helpful when I had a pre-order inquiry. Everything arrived in perfect condition, and the process from order to delivery was seamless. I am very satisfied with this transaction and would certainly consider them for future needs. The efficiency and professionalism displayed are commendable and make them a reliable source in this field. This positive first impression is crucial for establishing a trusted supplier relationship. I appreciate the attention to detail and the commitment to customer satisfaction that was evident throughout this simple purchase.
Xcellent experience overall. The shipping was remarkably fast, arriving well ahead of the estimated schedule. Packaging was secure and professional, ensuring the product arrived in perfect condition. Regarding quality, the product appears to be of very high purity as indicated, with no visible issues upon initial inspection. The service from Blue Sky Peptide was responsive and helpful throughout the ordering process. Communication was clear, and any inquiries were addressed promptly. This combination of efficient logistics, apparent high quality, and attentive service makes for a very positive procurement experience. I would certainly consider them for future peptide requirements based on this smooth transaction.
Delivery was exceptionally prompt and well-handled. The package arrived ahead of schedule, which was a pleasant surprise. Everything was securely packaged with appropriate materials to ensure the product's integrity during transit. The shipping process was transparent, with regular updates provided, making it easy to track the order from dispatch to arrival. This level of logistical efficiency is commendable and greatly appreciated, as it minimizes delays in important work. The courier service was professional, and the delivery was completed without any issues. Overall, the logistics experience was seamless and reliable, setting a high standard for service in this field. Such dependable shipping is crucial for planning and executing time-sensitive projects, and this supplier certainly delivers on that front. The attention to detail in packaging also prevented any potential damage, reflecting a strong commitment to customer satisfaction. From order placement to receipt, the entire process was smooth and hassle-free. This reliability in logistics not only meets but exceeds expectations, making future orders a certainty. The supplier's dedication to efficient delivery is evident and highly valued in a fast-paced research environment. Prompt service like this is a significant advantage, ensuring that projects can proceed without unnecessary interruptions. The overall handling of the shipment was impeccable, contributing to a positive and trustworthy relationship. I am thoroughly impressed by the logistical prowess demonstrated here, which adds tremendous value to the overall purchasing experience. This aspect of the service is a key reason for my satisfaction and continued patronage. Efficient logistics are often overlooked, but they play a vital role in the success of any procurement, and this supplier excels in that area. The timely delivery has consistently been a highlight, reinforcing confidence in their operations. Such dependable service is rare and should be acknowledged as a major strength. The seamless coordination from warehouse to doorstep is noteworthy and greatly facilitates workflow. This level of efficiency in delivery is a testament to their professional standards and customer-centric approach. I have no reservations in praising their logistical capabilities, which have consistently proven to be outstanding. The reliability and speed of delivery have made a significant positive impact on my work, and for that, I am very grateful. This supplier has set a benchmark in logistics that others should aspire to match. The entire delivery process was executed flawlessly, from packaging to final handover, ensuring a perfect end-to-end experience. Such meticulous attention to logistics details is highly commendable and greatly enhances the overall service quality. I am thoroughly pleased with how smoothly everything was handled, making this a standout aspect of their offering. The prompt and secure delivery has been a consistent feature, building a strong foundation of trust. This efficiency not only saves time but also reduces stress associated with waiting for essential materials. The supplier's commitment to excellent logistics is clear and much appreciated, making them a preferred choice for future needs. Overall, the delivery service was exemplary, contributing significantly to a positive overall impression and satisfaction.
Fantastic experience from start to finish. The shipping was incredibly fast and efficient, arriving well ahead of the estimated delivery date, which was a pleasant surprise. The packaging was secure and professional, ensuring the product arrived in perfect condition. Regarding the item itself, the quality appears to be exceptional; it was exactly as described and the presentation was impeccable. The customer service team was responsive and helpful, promptly answering my pre-purchase inquiries with clear and detailed information. Overall, the entire process was seamless and highly satisfactory. I am very impressed with the level of care and professionalism demonstrated throughout this transaction. This positive experience has certainly set a high standard and makes me confident in considering future orders. The combination of prompt logistics, apparent high quality, and excellent support is commendable.
My experience with Blue Sky Peptide was quite positive overall. The logistics were handled very efficiently; the package arrived much sooner than I had anticipated, which was a pleasant surprise. The shipping was well-organized, and I received timely tracking updates, allowing me to monitor the delivery progress without any issues. The packaging itself was secure and professional, ensuring the product was well-protected during transit. In terms of quality, the peptide powder appears to be of high standard, matching the description provided. It was sealed properly, and the labeling was clear and accurate, which is crucial for laboratory use. The service from the company was also commendable. The customer support team was responsive and helpful when I had a query prior to ordering, providing clear information promptly. The ordering process was straightforward, and the website was easy to navigate. While I cannot comment on the specific application or parameters of the PNC-27 peptide as per the guidelines, I can say that the overall transaction was smooth and reliable. The combination of fast shipping, apparent high quality, and excellent customer service makes this a supplier I would consider using again for future research needs. The attention to detail in both product presentation and customer interaction reflects well on their professionalism.
Arrived promptly with excellent packaging that ensured the product's integrity throughout transit. The quality appears top-notch, matching the high standards expected for research applications. Customer service was responsive and helpful when I had a quick question about the shipment. Overall, a very reliable experience from order to delivery.
Shipping was incredibly fast and reliable, which made the entire process smooth and stress-free. Service from the team was outstanding; they were responsive and helpful with all my inquiries. The quality of the product appears excellent, with careful packaging that ensured everything arrived in perfect condition. Overall, a very positive experience that I would highly recommend to others.
Rapid delivery and excellent packaging ensured my order arrived safely and on time. The quality of the peptide powder appears top-notch, with no visible issues upon inspection. Customer service was responsive and helpful throughout the process, addressing my queries promptly. Overall, a reliable experience from start to finish.
Delivery was incredibly fast and efficient, arriving well before the expected date. The quality of the packaging was excellent, ensuring the product remained secure and intact throughout transit. Customer service was responsive and helpful, promptly addressing my inquiries with clear and friendly communication. Definitely a reliable experience overall.
Just outstanding experience overall! The delivery was incredibly fast and well-handled, arriving much sooner than anticipated without any delays. Packaging was secure and professional, ensuring the product reached me in perfect condition. Quality-wise, everything appears top-notch based on initial checks, with no visible issues or concerns. Customer service was prompt and helpful, answering all my queries efficiently. I'm thoroughly impressed and would definitely recommend this supplier for their reliability and excellence.