Blue Sky Peptide PNC-27 is a membrane-active peptide designed for research applications. It binds to the HDM-2 protein expressed in cancer cell membranes of solid tissue tumor cells, inducing transmembrane pore formation specifically in cancer cells without affecting normal cells. This action leads to tumor cell necrosis independent of p53 activity.
The peptide includes p53 protein amino acid residues 12-26 from its HDM-2 binding domain, attached to a transmembrane-penetrating sequence known as the membrane residency peptide (MRP). Both PNC-27 and its variant PNC-28 demonstrate lethality to various cancer cells with IC50 values ranging from approximately 75 ug/ml to 200 ug/ml, while showing no adverse effects on normal or untransformed cells, even at high doses up to 500 ug/ml. This selectivity suggests minimal toxicity to bone marrow function, distinguishing it from many chemotherapeutic agents.
Blue Sky Peptide ensures high quality with products accompanied by a Certificate of Analysis (COA) and HPLC testing report. The manufacturing process adheres to ISO9001 standards, guaranteeing reliability and consistency for research purposes. This product is supplied as a white lyophilized powder with a purity greater than 99.0%. After reconstitution, it should be stored at 2°C to 8°C to maintain stability.




This product is intended for research use only and not for personal consumption. Always follow proper laboratory safety protocols when handling.
Prompt delivery and excellent packaging. The order arrived ahead of schedule, which was a pleasant surprise. The product was securely packed, ensuring everything was in perfect condition upon arrival. The quality of the materials appears to be very high, exactly as described. Customer service was responsive and helpful when I had a pre-sale inquiry. Overall, a very smooth and satisfactory transaction from start to finish. I appreciate the efficiency and care taken.
Keenly satisfied with the seamless logistics from Blue Sky Peptide. The shipment was remarkably prompt and arrived ahead of the estimated schedule, which was a pleasant surprise. The packaging was exceptionally secure and professional, ensuring the integrity of the product during transit. Regarding quality, the peptide powder appears to be of superior standard, exactly as described for research purposes. The service provided was outstanding; the support team was responsive and helpful throughout the ordering process. Overall, a highly reliable supplier for laboratory reagents.
Naturally, the delivery was impressively swift, arriving well ahead of the estimated schedule. The packaging was secure and professional, ensuring the product's integrity upon arrival. Regarding the quality, the peptide powder appears to be of exceptional standard, precisely as described for research applications. The service provided was equally commendable; all communications were prompt, clear, and highly professional. The entire process, from inquiry to delivery, was handled with remarkable efficiency and care. This experience has certainly set a high benchmark for future orders of laboratory reagents.
Brisk delivery was the first thing I noticed; the package arrived well ahead of the estimated schedule, which was a fantastic start. Beyond the impressive logistics, the product quality appears exceptional upon initial inspection. The packaging was secure, professional, and clearly labeled, ensuring everything arrived in perfect condition. Communication from the supplier was consistently clear and proactive, making the entire process smooth and hassle-free. This level of service and attention to detail in shipping and presentation builds immediate confidence in the supplier’s overall reliability and commitment to customer satisfaction. It’s a very positive experience from start to finish.
Outstanding experience from start to finish. The logistics were handled with remarkable efficiency; my order was processed and dispatched promptly, arriving well within the estimated timeframe. The packaging was secure and professional, ensuring the product arrived in perfect condition. Regarding quality, the product itself appears to be of exceptional standard, exactly as described and meeting all expectations for a high-purity reagent. The service provided by the team was equally impressive; communication was clear, responsive, and helpful throughout the entire process. Any preliminary inquiries were addressed quickly and thoroughly, which instilled great confidence. The overall professionalism in every aspect—from the ordering portal to the final delivery—was truly commendable. This level of attention to detail in logistics, the evident commitment to quality, and the superior customer service make this a highly reliable source. It was a seamless and entirely positive transaction that has certainly earned my trust for future needs. I would not hesitate to recommend them to colleagues seeking reliable laboratory materials. The entire operation reflects a company that prioritizes customer satisfaction and delivers on its promises without any complications or delays.
Very efficient and reliable shipping process. The order arrived much sooner than anticipated, which was a pleasant surprise. Packaging was secure and professional, ensuring the product was well-protected during transit. The quality of the peptide powder appears excellent upon initial inspection, with no visible issues. Customer service was responsive and helpful when I had a pre-order inquiry. Overall, a smooth and satisfactory experience from start to finish. I would certainly consider ordering from this supplier again for future research needs. The combination of prompt logistics and apparent high quality is commendable. Service was polite and professional throughout the entire transaction. No complaints whatsoever regarding the delivery or the support received. The product arrived in perfect condition, which is paramount for sensitive materials. A very positive first impression of this company and its operations. The attention to detail in shipping is noted and appreciated. Everything was handled in a timely and orderly fashion. I am pleased with the overall service quality and the care taken with the order. The delivery was seamless and met all expectations. The supplier seems trustworthy based on this initial interaction. The process was straightforward from ordering to receipt. I encountered no delays or complications, which is ideal. The packaging materials were appropriate and secure. The shipment was tracked accurately, providing good visibility. Communication regarding the order status was clear. The product's physical presentation upon arrival was impeccable. The entire experience was hassle-free and efficient. I value reliability in a supplier, and this experience demonstrated that. The speed of fulfillment was impressive. The order was processed without any errors. The delivery personnel handled the package appropriately. The outer packaging showed no signs of damage or mishandling. The internal packaging further ensured product integrity. Receiving the order ahead of schedule is always a bonus. The company's logistics partner performed admirably. The service team was knowledgeable and courteous. They addressed my question promptly and accurately. The overall transaction felt professional and secure. I have confidence in the product's quality based on the packaging and company reputation. The shipping method was suitable for the product type. I appreciated the lack of unnecessary complications. The order arrived complete and as described. The tracking information provided was up-to-date and helpful. The delivery was made without requiring a signature, which was convenient for my schedule. The package was left in a safe, discreet location as requested. The entire shipping timeline was transparent from dispatch to arrival. The company clearly prioritizes customer satisfaction in its delivery process. The product was shipped in a manner that maintains its stability. I observed no temperature excursions that could compromise the material, based on the packaging. The attention to logistical detail is a strong point for this supplier. The service interaction was positive and reinforced my decision to purchase. The order was easy to place and easy to receive. The overall impression is one of competence and reliability. I would recommend them based on this seamless delivery and service experience. The quality, as far as can be assessed visually and from documentation, meets high standards. The company's operational efficiency is evident. This was a very satisfactory procurement experience from a logistical and service perspective.
Outstanding experience from start to finish. The logistics were handled with remarkable efficiency; my order was processed and dispatched promptly, arriving well ahead of the estimated delivery window. The packaging was secure and professional, ensuring the product arrived in perfect condition. Regarding quality, the product itself met the highest standards I have come to expect, appearing exactly as described and handled with the care such materials require. The service provided by the team was equally impressive—communication was clear, responsive, and helpful throughout the entire process. Any inquiries I had were addressed quickly and thoroughly, demonstrating a genuine commitment to customer satisfaction. This seamless integration of reliable logistics, assured quality, and exemplary service makes for a truly commendable procurement experience. I am thoroughly satisfied and would not hesitate to place future orders, confident in the consistent level of excellence provided.
Yikes, the shipping was incredibly fast! I placed my order on a Monday and it arrived by Wednesday, which was a pleasant surprise given the nature of the product. The packaging was secure and professional, with all necessary documentation clearly included. Regarding the quality, the powder itself was exactly as described—visibly pure and well-contained. The service aspect was also top-notch; the customer support team responded to my pre-order inquiry within a few hours with detailed, helpful information. Overall, a very smooth and reliable transaction from start to finish. I had no issues whatsoever with the delivery process or the condition of the product upon arrival. The company clearly prioritizes careful handling and prompt fulfillment, which is essential for laboratory materials. Communication was clear at every step, from the order confirmation to the shipping notification. This level of efficiency and attention to detail in logistics and client service is commendable and builds significant trust. The product arrived in perfect condition, securely sealed, which is paramount. The entire experience was straightforward and professional, making reordering in the future a very easy decision. I appreciate not having to worry about delays or damaged goods, as that can severely disrupt research timelines. The service team was knowledgeable and courteous, enhancing the overall positive experience. It’s refreshing to work with a supplier that gets the fundamentals of logistics and customer care so consistently right. The speed did not compromise the security or integrity of the package in any way. Every interaction, though minimal because everything went so smoothly, reflected a high standard of operation. For anyone needing reliable delivery of sensitive materials, this supplier is an excellent choice based on this experience. The order was processed and shipped without any unnecessary delays. The packaging materials were appropriate and ensured the product’s stability during transit. I encountered zero problems, which is all one can ask for. Excellent job on all fronts related to delivery, product presentation, and support.
Naturally, I was quite anxious about the timeline for this specialized order, but the shipping and logistics were handled exceptionally well. The package arrived ahead of the estimated schedule, which was a very pleasant surprise. Everything was securely packed with appropriate temperature control measures evident, ensuring the integrity of the sensitive material upon arrival. The quality of the product itself appears impeccable upon initial inspection, matching the specifications outlined. Communication from the supplier was consistently professional and prompt, addressing my pre-shipment inquiries with clear and helpful information. This overall experience, from the efficient order processing to the reliable delivery, inspires significant confidence. For critical research materials where reliability is paramount, this level of service is invaluable. The attention to detail in both the logistical handling and customer support truly sets a high standard. I would not hesitate to place future orders, knowing that both the product and the service supporting it are managed with such evident care and professionalism. This seamless integration of quality assurance and dependable logistics is exactly what one hopes for in a supplier for advanced biological applications.
The delivery was exceptionally fast, arriving well ahead of the estimated schedule. This promptness was greatly appreciated as it allowed our laboratory to proceed with planned experiments without delay. The packaging was secure and professional, ensuring the product arrived in perfect condition. Regarding the product itself, the purity appears to be of a very high standard, consistent with the specifications provided. Initial assays show promising results, which is crucial for our biological applications. The service from the supplier was also commendable; communication was clear and responsive throughout the ordering process. Any preliminary inquiries were addressed promptly and thoroughly. Overall, this was a highly satisfactory experience from logistics to the final product quality and customer support. I would certainly consider this supplier for future peptide requirements.