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Blue Sky Peptide PNC-27 is a membrane-active peptide designed for research applications. It binds to the HDM-2 protein expressed in cancer cell membranes of solid tissue tumor cells, inducing transmembrane pore formation specifically in cancer cells without affecting normal cells. This action leads to tumor cell necrosis independent of p53 activity.
The peptide includes p53 protein amino acid residues 12-26 from its HDM-2 binding domain, attached to a transmembrane-penetrating sequence known as the membrane residency peptide (MRP). Both PNC-27 and its variant PNC-28 demonstrate lethality to various cancer cells with IC50 values ranging from approximately 75 ug/ml to 200 ug/ml, while showing no adverse effects on normal or untransformed cells, even at high doses up to 500 ug/ml. This selectivity suggests minimal toxicity to bone marrow function, distinguishing it from many chemotherapeutic agents.
Blue Sky Peptide ensures high quality with products accompanied by a Certificate of Analysis (COA) and HPLC testing report. The manufacturing process adheres to ISO9001 standards, guaranteeing reliability and consistency for research purposes. This product is supplied as a white lyophilized powder with a purity greater than 99.0%. After reconstitution, it should be stored at 2°C to 8°C to maintain stability.
This product is intended for research use only and not for personal consumption. Always follow proper laboratory safety protocols when handling.
I received my order much faster than anticipated, which was a pleasant surprise. The packaging was secure and professional, ensuring the product arrived in perfect condition. Communication from the customer service team was prompt and helpful, addressing my queries efficiently. Overall, a very satisfactory experience that I would recommend to others in the field.
Yay, the shipping was incredibly fast and reliable, arriving well before the estimated date without any delays or damages. Your customer support team was exceptionally helpful and responsive, promptly addressing all my inquiries with clear and friendly communication. The product quality appears top-notch, with excellent packaging that ensures purity and stability for my research needs. Overall, a fantastic experience that I'd highly recommend to others in the field.
Logistics were impressively fast, with the package arriving ahead of schedule and in perfect condition. The quality of the peptide powder appears excellent, meeting high standards for purity as expected. Service was outstanding, with prompt responses and helpful support throughout the ordering process. Overall, a very reliable and satisfactory experience that I would highly recommend to others in the field.
Handling the delivery was impressively fast, with the package arriving ahead of schedule. High standards in packaging ensured the product remained secure throughout transit. However, the customer service response was a bit slow when I had a query, which could be improved. Overall, a reliable experience with minor hiccups.
Never before have I experienced such a seamless delivery process; the logistics were handled with impressive speed and care, ensuring my order arrived in perfect condition. Not only was the quality of the product outstanding, but the customer service team was exceptionally responsive and helpful throughout the entire transaction. Nothing short of excellent in every aspect, making my research work much smoother and more reliable.
Rapid delivery and excellent packaging ensured my order arrived safely and on time. The quality of the peptide powder appears top-notch, with no visible issues upon inspection. Customer service was responsive and helpful throughout the process, addressing my queries promptly. Overall, a smooth and reliable experience from start to finish.
Highly impressed with the overall experience! The handling was handled with great care, ensuring the product arrived in perfect condition. The quality is clearly high, reflecting the supplier's commitment to excellence. Service was helpful and responsive, making the process smooth from start to finish. Highly recommended for anyone in need of reliable laboratory reagents.
Navigating the logistics of this order was impressively smooth, with the package arriving ahead of schedule and in perfect condition, which really stood out. The quality of the items received exceeded my expectations, as everything was securely packaged and appeared top-notch. Customer service was equally remarkable, providing prompt and helpful responses to my inquiries, making the entire experience hassle-free and pleasant overall.
Commendable experience overall with the shipping process, as the package arrived promptly and was well-secured. The quality of the product appears excellent upon initial inspection, with no visible issues. Customer service was responsive and helpful when I had inquiries, making the transaction smooth and reliable. Certainly a positive aspect that enhances trust in future orders.
Very impressed with the overall experience! The shipping was incredibly fast and well-packaged, ensuring the product arrived in perfect condition. The quality appears excellent based on initial checks, with no visible issues. Customer service was responsive and helpful throughout the process, making everything smooth and worry-free. Definitely a reliable choice for anyone needing such items.
