Retatrutide/">Retatrutide/">Retatrutide/">Retatrutide/">Retatrutide/">Retatrutide/">Retatrutide/">Retatrutide/">Retatrutide is a novel triple agonist peptide that simultaneously targets glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). This unique mechanism makes it particularly valuable for metabolic research applications.
As a white powder with pharmaceutical grade purity exceeding 99%, Retatrutide demonstrates potent activity across multiple receptor targets. Research indicates EC50 values of 5.79 nM for GCGR, 0.0643 nM for GIPR, and 0.775 nM for GLP-1R in human studies. Comparable activity has been observed in mouse models with EC50 values of 2.32 nM (GCGR), 0.191 nM (GIPR), and 0.794 nM (GLP-1R).
The compound's ability to activate glucagon receptors leads to significant metabolic effects including increased energy expenditure and weight reduction. Research applications include studying glucose tolerance improvement through GIP or GLP-1 receptor pathways in ipGTT models.
Clinical research data suggests Retatrutide may support substantial weight management effects, with studies showing potential for significant body weight reduction. The compound also demonstrates potential benefits for blood glucose regulation and metabolic parameters.
This research compound is provided as a white powder with molecular weight of 4731.33 g/mol. Proper storage at -20°C is recommended to maintain stability, with a typical shelf life of 24 months when stored appropriately.