High Purity TB-500 Peptide Powder 99% CAS 885340-08-9 - Bulk Orders

Actually ordered this after we needed something with consistent purity across multiple vials for a series of comparative assays we're finally validating—our regular supplier has been spotty on delivrey times, so this batch from them is a stopgap more than anything. 99% by HPLC is tight enough that our company can ditch the extra recrystallization step I had budgeted for with reagent grade material, which saves about 3 days per run. Store it at -20°C, we keep ours in a dedicated freezer with a temp logger, and that shelf life is 24 months usually but we'll burn through these well before that.

The solubility in both water and methanol is what makes handling easier than the acetate salts I've used before—just reconstitute in sterile water for the cell work or in methanol for the LC-MS prep. It's a white powder, fine enough that static cling can be a pain when you're weighing out sub-milligram doses, but the 10mg vials are small enough to avoid that unless you're splitting them. Also, the CAS 885340-08-9 tracks, but I've seen some lots from other suppilers where the actual activity felt off even when HPLC showed okay numbers, so we'll run a quick bioassay on this first shipment. Most labs go with the 15mg vial for muscle repair work if they're making stock solutions—less pipetting hassle.

What it isn't for is anything with prolonged systemic exposure unless you're doing very specific angiogenesis studies—the thymosin beta-4 fragment has that actin-binding domain that can throw off certain migration assays if you don't control for the free peptide concentration. It's really for regenerative endpoints in vitro or maybe topical formulations in wound models, not general anti-inflammatory screens where you'd want a smaller molecule. One thing nobody mentions: this stuff can be a bit hygroscopic over time, even sealed, so we've started pulling vials out to acclimate at room temp before weighing anything.

Teh molecular weight, 889.02 g/mol, is worth knowing for molarity calculations—it's on the heavier side for a peptide, so reconstitution volumes are roughly 2 times less than what you'd use for a 500 g/mol compound. Solubility is good at 20 mg/mL in water or methanol, though you can hit some opalescence at high concentrations in saline. For bulk orders, they quote 10-vial boxes which actually means each box has individual vials packed with desiccant, not a single gram in a jar—so if you're doing large-scale work you'll want to confirm the total count.

And the price per milligram drops significantly above 20 vials—something like 30% less than retail, but check the lead time because they seem to ship from a consolidation facility in Shanghai, usually 7 to 12 days. They'll send COAs per batch, trust but verify on the HPLC traces, and we always run a full QC panel before any in vivo injection. Honestly, for the price point it's better than reagent grade form the large distributors if you just need clean materail for characterization work, but if you're running pharmacokinetics you might want to push for their ISO-certified line instead—this doesn't have that third-party screening.