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Sincalide CCK-8 is a synthetic C-terminal octapeptide identical to the sequences of the endogenous cholecystokinin hormone. This research-grade peptide is provided as a white lyophilized powder with minimum 99% purity.
The peptide mimics the action of cholecystokinin, inducing gallbladder smooth muscle contraction directly. This action reduces gallbladder size, promotes bile evacuation, and stimulates secretion of pancreatic enzymes. Additionally, Sincalide decreases esophageal sphincter tone and delays gastric emptying through cholinergic signaling pathways.
In clinical research settings, Sincalide CCK-8 has been used to examine pancreatic exocrine function when combined with pancreatin. It has also shown potential for use in cholecystography studies where it can replace fat meals to promote intestinal peristalsis and shorten examination times. Research applications may include studies of intestinal paralysis treatment.
This product is provided for laboratory research use only. All potential applications described are based on published literature and have not been evaluated by regulatory agencies for clinical use.
