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Bivalirudin Trifluoroacetate is a high-purity synthetic peptide with a molecular weight of 2295.32 g/mol. This white lyophilized powder demonstrates excellent stability and is slightly soluble in water. The peptide sequence consists of 20 amino acid residues: D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH.
As a potent thrombin inhibitor, Bivalirudin reversibly binds to the active site of thrombin, preventing the conversion of fibrinogen to fibrin - a critical step in thrombus formation. This mechanism makes it particularly valuable for cardiovascular research applications.
In laboratory studies, Bivalirudin has shown inhibitory effects on both soluble and thrombus-bound thrombin. Its activity is not affected by platelet-derived products and demonstrates dose-dependent effects on plasma coagulation parameters including activated partial thromboplastin time, thrombin time, and prothrombin time.
This research chemical is supplied as a lyophilized powder with purity exceeding 99.0%. After reconstitution, proper storage at 2-8°C is recommended to maintain stability. The product is intended for research purposes only and is not for human consumption.
Important Note: This product is supplied for laboratory research use only. The described applications and potential effects are based on published literature and have not been evaluated by regulatory agencies for medical use.
